several years ago, a man noticed a small mole on his wrist. years later, the mole grew in size and the man was diagnosed as having metastatic melanoma. this was likely the result of: please choose the correct answer from the following choices, and then select the submit answer button. answer choices several mutations affecting proto-oncogenes and/or tumor suppressor genes. a single mutation inactivating a tumor suppressor gene. a single mutation affecting one proto-oncogene in a cell. none of the other answer options is correct; cancers arise spontaneously, independent of mutations.