All of the following regarding Acute tubular necrosis (ATN) and CKD are true EXCEPT?
1) GFR is greatly increased in ATN
2) ATN is characterized by the destruction of tubular epithelial cells with acute suppression of renal function
3) ATN can be caused by acute tubular damage due to sepsis
4) With respect to CKD, the lower the number of functioning nephrons, the lower the GFR