I am learning about cell adhesion molecules (CAMs), and I know that they mediate cell-cell and cell-extracellular matrix adhesion via homophilic and heterophilic interactions. I have read that CAMs can be divided into four families based on their protein sequence and structure, including the immunoglobulin superfamily, integrins, cadherins and selectins.
I know that immunoglobulin superfamily CAMs are defined as having immunoglobulin domains in their extracellular domain.
However, I was wondering if a protein has immunoglobulin domains in the extracellular domain but a protein kinase domain in the intracellular domain (e.g. TYRO3), can it still be classified as a cell adhesion molecule belong to the immunoglobulin superfamily?
I know that the intracellular domains of CAMs can interact with cytoplasmic proteins, thus regulating intracellular signalling cascades. However, I have never read about CAMs themselves having any intrinsic enzymatic activity.
Any insights are appreciated.