Which of the following statements about the secretion and transport of adiponectin are TRUE? (select all that apply)

a. As adipocytes become larger due to increased lipid storage, the secretion of adiponectin decreases.
b. One mechanism for reduced adiponectin section is increased FFA action on the adipocytes.
c. The transport of adiponectin in the circulation requires attachment to binding globulins such as albumin.
d. Adiponectin transport across the endothelium of the vasculature in skeletal muscle tissue is by simple diffusion.