Adherence is critical to successful antiretroviral therapy. When counseling a patient on his antiretroviral regimen, which of the following statements regarding adherence would be most accurate?
A. To achieve the best outcome, the patient must never miss a dose. If he/she misses a dose, resistance will develop, and we will not be able to treat the HIV.
B. Everyone misses doses occasionally. If the patient misses a dose or two every couple of days, it is not a problem as long as he/she doubles the dose on the days missed.
C. Everyone misses doses occasionally; however research has shown to achieve the best control of your HIV infection, the patient should take 95 out of every 100 doses (or more) as prescribed by the physician.
D. Everyone misses doses occasionally; however research has shown to achieve the best control of your HIV infection, the patient should take 75% of prescribed doses.
E. As long as protease inhibitors are boosted with ritonavir and all antiretrovirals are taken with food to facilitate absorption, missing doses becomes irrelevant.