David, a 19-year-old college student, has a family history of schizophrenia. During a neuroscience lecture, Professor Rudyk discusses the potential impact of substance use on individuals with genetic susceptibility to schizophrenia. Given David's case and his family history, which substance has been implicated in potentially exacerbating brain mutations associated with schizophrenia when individuals with gene mutations engage in its use?
a) Ketamine
b) Cannabis
c) NDMA
d) Psilocybin