Parietal cells produce gastric acid (hydrochloric acid) in response to histamine (via H2 receptors), acetylcholine (M3 receptors) and gastrin (gastrin receptors). Parietal cells contain an extensive secretory network (called canaliculi) from which the HCl is secreted by active transport into the stomach.
Parietal cells produce gastric acid (hydrochloric acid) in response to histamine (via H2 receptors), acetylcholine (M3 receptors) and gastrin (gastrin receptors).
Parietal cells secrete acid in response three types of stimuli:
Histamine, stimulates H2 histamine receptors (most significant contribution).
Acetylcholine, from parasympathetic activity via the vagus nerve and enteric nervous system, stimulating M3 receptors.
Thus,Parietal cells contain an extensive secretory network (called canaliculi) from which the HCl is secreted by active transport into the stomach.
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