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Which one of the following enzymes of nucleotide metabolism is correctly paired with its pharmacologic inhibitor?

A. Dihydrofolate reductase—methotrexate

B. Inosine monophosphate dehydrogenase—hydroxyurea

C. Ribonucleotide reductase—5-fluorouracil

D. Thymidylate synthase—allopurinol

E. Xanthine oxidase—probenecid

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Answer:

A. Dihydrofolate reductase—methotrexate

Explanation:

Dihydrofolate reductase is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid. Methotrexateis its inhibitor. It interferes with folate metabolism by acting as a competitive inhibitor of the enzyme.

Since folateis necassary for rapid dividing cells, such as cancer cells, methotrexate can be used as anticancer drug that inhibits DHFR.

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