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Bone formation begins when ____________ secrete the initial semisolid organic form of bone matrix called ____________ . Calcification, or mineralization, then occurs when ____________ crystals deposit in the bone matrix. These crystals form when calcium and phosphate ions reach critical levels and precipitate out of solution and deposit in and around the ____________ fibers. The entire process of bone formation requires a number of substances, including ____________ (which enhances calcium absorption from the GI tract) and ____________ (which is required for collagen formation), as well as calcium and phosphorus for calcification.

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Answer:

Bone formation begins when osteoblats secrete the initial semisolid organic form of bone matrix called osteoid. Calcification, or mineralization, then occurs when hydroxyapatite crystals deposit in the bone matrix. These crystals form when calcium and phosphate ions reach critical levels and precipitate out of solution and deposit in and around the collagen fibers. The entire process of bone formation requires a number of substances, including vitamin D (which enhances calcium absorption from the GI tract) and vitamin C (which is required for collagen formation), as well as calcium and phosphorus for calcification.