Explain the events of the sliding filament theory of skeletal muscle contraction beginning with immediately after the release of Ca from the sarcoplasmic reticulum and ending at the end of one cross bridge cycle. Describe how asynchronous multiple cross bridge cycles affect the sarcomere. What are the roles of ATP in muscle contraction?

Respuesta :

Explanation:

  1. Nerve impulse to the muscle causes the release of calcium ions for the sarcoplasmic reticulum
  2. The calcium bind to their binding site on the troponin of the actin. This causes a displacement to expose myosin-binding site on the tropomyosin of the actin filament.
  3. Myosin head binds to its active site on the actin forming an actinomyosin bridge
  4. ATP binds to its site on the myosin head
  5. The hydrolysis of ATP causes the myosin to pull on the actin, in rowing action, and this causes the actin and myosin to move antiparallel to each other
  6. The release of the ADP + Pi from the ATP myosin site cause the myosin to disengage the actin and resume its initial position and binding the next forward myosin-binding site on the actin
  7. This causes a decrease in distance between the Z-lines of a sarcomere and this is a contraction of the muscle.

Different myosin heads are at different stages of the cycle (asynchronous multiple cross bridge cycles). This allows the myosin and actin to continue moving antiparallel, even while some myosin heads are disengaged from their myosin-binding sites on the  actin, without losing the contraction (this would happen if they all disengage at the same time).

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