Which complication may be increased because of the combined use of catechol ortho-methyltransferase (COMT) inhibitors and monoamine oxidase inhibitors (MAOIs)?

Catechol ortho-methyltransferase (COMT) and monoamine oxidase (MAO) is used for the catalysis of the first step of the catecholamine metabolism. COMT is present in neurons membrane whereas MAO is located on the outer membrane of mitochondria.

The inhibitors of monoamine oxidase and Catechol ortho-methyltransferase result in the improper metabolism of the catecholamines. These decreased metabolism results in the increase of the cardiovascular disease of the body. This affect the other functioning of the body as well.

Thus, the answer is increased cardiovascular risk.

Histrionicus Histrionicus · Answer 2 · 2020-01-23T07:11:27+01:00

ANSWER:

The correct answer is : increased risk of the cardiovascular disease.

Explanation:

Using the XCOMT and MAOIs together can lead to the high risk of cardiovascular disease due to the using these altogether cause lowering catecholamines.

There are several other condition can be arise due to not taking as prescribed such as taking COMT inhibitors empty stomach that result in GI upset however there is no direct impact on GI tract.

Thus, the correct answer is - increased risk of the cardiovascular disease.