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Question 1 (2 points)
Different forms of ovarian cancer can be either hereditary or sporadic (NOT due to
an inherited gene mutation). Over 80% of sporadic ovarian cancers are caused by
mutations in the p53 and/or PRB genes.
Below you will find the normal p53 gene found on chromosome 17
AAA TTG CAG TAG
TTT AAC GTC ATC
Using the triplets from the lower strand, transcribe mRNA and write those codons in
the box below.
​

Respuesta :

The amino acids coded triplets in the 3' to 5' strand on the normalp53 gene of chromosome 13 are lysine, leucine, Glutamine, stop codons.

Explanation:

mRNA is formed by the transcription of DNA strand coding for  a gene.

Any mutation in the DNA sequence even a difference of base pair would cause formation of different amino acids and hence altered protein.

The amino acid is formed in the step of translation where codes are read by tRNA on the mRNA strand and correct nucleotide is brought to growing polypeptide chain.

In transcription 3' to 5'  strand acts a template strand. The amino acids on the p53 gene of chromosome 17 is

3'TTT AAC   GTC    ATC 5'    Gene sequence

5' AAA UUG CAG   UAG 3'   mRNA

lysine, leucine, Glutamine, stop

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