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Erythroblastic anemia is a disturbance of the hematopoietic system. characterized by a constant racial and familial incidence, a typical facial. appearance, a progressing anemia with large numbers of nucleated. erythrocytes in the peripheral blood, enlargement of the spleen,
e·ryth·ro·blas·tic a·ne·mi·a. anemia characterized by the presence of large numbers of nucleated red blood cells (normoblasts and erythroblasts) in the peripheral blood. Seen in newborns with hemolytic anemia, due to isoimmunization, such as that caused by Rh or ABO incompatibility. See also: erythroblastosis fetalis.