Answer:
I believe it would be having biological parents who are or were substance abusers and having role models ( such as parents or people they look up to) who abuse drugs or alcohol.
Explanation:
If I am wrong, please tell me, but just because of having a novelty and like risk-taking will not make you more likely to take drugs, and dopamine I don't think would. If you do some research you will most likely find that people who have parents that were drug or alcohol abusers and people who started taking drugs or drinking alcohol probably did this because they saw their peers or people they admire did drugs or abused alcohol. Thanks, and I hope this helps!