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Cells enter a futile substrate cycling during which increased intracellular glucose overwhelms the TCA cycle. As a result, non-oxidative glucose metabolism ____ producing _______.

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lunermoon

Explanation: Reciprocal regulation is intended to prevent concurrent activity in two closely parallel pathways, as represented by gluconeogenesis and glycolysis. These pathways include potential futile cycles, which would simply waste ATP if allowed to run freely.

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