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A substantial imbalance between demand and response capability under conditions in which failure has important consequences refers to.

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A substantial imbalance between demand and response capability under conditions in which failure has important consequences refers to STRESS. It may affect the functioning of a biological system.

Homeostasis and stress

Homeostasis refers to the state of internal (steady) equilibrium, which is required for the normal functioning of a biological system.

Conversely, stress can be defined as any environmental factor (e.g., excessive temperature condition) which is directly affecting the normal functioning of an organism.

Stress may lead to the loss of the homeostatic state when conditions cannot be supported by the organism.

Learn more about stress here:

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