Answer: D
Explanation: "accursed: used to express strong dislike of or anger toward someone." (But it can also be used in the more literal sense, as someone who has been cursed)
If these people are accursed, they're strongly disliked, so everyone is "making their mock at their accursed lot" or making fun of them.
A general rule of thumb as well is that the phrase in the same sentence as the word you don't know is likely to provide the most context clues.
