Physical contact of cell-surface proteins between adjacent cells probably the main factor responsible for the phenomenon of density-dependent inhibition.
How is density-dependent inhibition generated?
- Anchored cells divide on dish surfaces (anchorage dependence). Cells stop dividing once a single layer of all of them has been produced (density-dependent inhibition).
- When some cells are removed, the remaining ones divide to fill the void before stopping (density-dependent inhibition).
- Cells can only grow to a certain density before growth is blocked, potentially through cell-cell interactions.
- This is known as density-dependent inhibition. Frequently, density-dependent inhibition has been lost in tumor cells.
- The density-dependent in vitro suppression of mammalian cell growth is a good illustration of such adverse growth regulation.
- The interaction of several cell membrane components, which results in growth-inhibition after cell-cell contact, would seem to be the most logical explanation for this phenomena.
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