The first 90 amino acids of cyclin are necessary for anaphase onset and activation of separase. They are also sufficient for anaphase onset and the degradation of securin.
What are cyclins and separase?
Cyclins are specific cellular proteins that control the progression through the cell cycle.
Separase is a protease enzyme that triggers the initiation (onset) of anaphase by the hydrolysis of cohesin.
Separase can be activated by degrading the securin inhibitor and the elimination of inhibitory phosphates.
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