Complete question:
A prescription calls for 50 mg of chlorpheniramine maleate. Using a prescription balance with a sensitivity requirement of 6 mg, explain how you would obtain the required amount of chlorpheniramine maleate with an error not greater than 5%.
Answer:
The smallest quantity that should be weighed on the balance:
Sensitivity requirement (SR) = 0.006 gm = 6 mg
Why chlorophenarimine is required?
Chlorpheniramine treats allergies, hay fever, and the common cold by easing symptoms such as runny nose, itchy, watery eyes, sneezing, itchy throat, and red eyes. Chlorpheniramine aids in the management of cold and allergy symptoms, but it does not address the underlying source of the symptoms or hasten recovery.
There is a need of 0.012 gm of drug = 12 mg
% error = 5%
Lactose diluent
Minimum weighble quantity = SR / % error (in decimal)
6 mg / 0.05 = 120 mg or 100% x 6 mg / 5% = 120 mg
so A / B = C / D
Whereas A- Drug
B- Lactose + drug
C- amount of drug
D- Aliquot
Therefore 120 / B = 12 / 120
B (12) = (120) (120)
B = 1200 mg
1200- 120 = 1080 mg diluent
Weigh 120 mg drug
dilute it with 1080 mg lactose diluent to make 1200 mg, weigh aliquot 120 mg.
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