Since the ES complex would be in a "energy trough," the activation energy for the transition state would be quite high.
What is enzyme?
- Tight enzyme substrate binding will lower the reaction's forward rate constant.
- A forward reaction's activation energy will increase when an enzyme's affinity for its substrate is high.
- Because the enzyme-substrate complex will be located in a deep energy well, it will be more stable.
- In contrast to the situation where the substrate-enzyme binding is weaker, a tight binding of the substrate to the enzyme will alter the amounts of free substrate and free enzyme.
- This little modification won't have much of an impact on the reaction kinetics because the substrate concentration is often higher than the enzyme concentration.
- It is unlikely that tight binding would result in the active site being altered.
- Since the enzyme is significantly bigger than the substrate, it is unlikely that it will change shape.
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