Wu, S. F. et al. Hydroxychloroquine inhibits CD154 expression in CD4( ) T lymphocytes of systemic lupus erythematosus through NFAT, but not STAT5, signaling. Arthritis Res. Ther.19, 183 (2017)

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21-07-2022
Biology

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Wu, S. F. et al. Hydroxychloroquine inhibits CD154 expression in CD4( ) T lymphocytes of systemic lupus erythematosus through NFAT, but not STAT5, signaling. Arthritis Res. Ther.19, 183 (2017)

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Tutorconsortium365 Tutorconsortium365 · Answer 1 · 2022-08-02T11:01:24+02:00

The given statement that Hydroxychloroquine inhibits CD154 expression in CD4( ) T lymphocytes of systemic lupus erythematosus through NFAT, but not STAT5, signaling holds true.

What is the role of HCQ in the treatment of SLE?

Overexpression of membranous CD154 in T lymphocytes has been found previously in systemic lupus erythematosus (SLE). Because hydroxychloroquine (HCQ) has been used frequently in the treatment of lupus, we sought to identify the effects of HCQ on CD154 and a possibly regulatory mechanism.

HCQ treatment had significant dose-dependent suppressive effects on membranous CD154 expression in ionomycin-activated T cells from lupus patients. Furthermore, HCQ inhibited intracellular sustained calcium storage release, and attenuated the nuclear translocation of NFATc2 and the expression of NFATc1. However, CD154 expressed through IL-15-mediated STAT5 signaling was not inhibited by HCQ treatment.

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