Metformin and longevity (METAL): a window of opportunity study investigating the biological effects of metformin in localized prostate cancer is totally based on the working of metformin .
What is Metformin?
- A biguanide oral hypoglycaemic drug called metformin is frequently prescribed to treat type 2 diabetes mellitus. Metformin has been linked to a decreased risk of cancer incidence of a number of solid tumors, including prostate cancer, in addition to its anti-diabetic impact (PCa).
- The biochemical mechanisms behind these observations in PCa have not yet been thoroughly characterized. The formation and progression of PCa are thought to be influenced by high insulin and insulin-like growth factor-1 (IGF-1) levels, hence one theory is that the indirect insulin reducing impact may have an anti-neoplastic effect.
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