A Final statement or concluding statement
Despite common clinical anticipation that many patients would respond to immune-checkpoint inhibitors, the frequency of microsatellite instability (MSI) is reportedly exceedingly low in breast cancer (ICI).
Given that some triple-negative breast cancers (TNBC) responded well to ICI in a clinical trial and that a high density of tumor-infiltrating lymphocytes (TILs) is frequently observed in other cancers with high levels of microsatellite instability (MSI-H), we hypothesized that some TNBC with a high density of TILs would be MSI-H.
TILs are abundant in medullary carcinoma of the breast (MedCa), an uncommon histological form. Given that MedCa in the colon is frequently MSI-H, we predicted that MedCa in breast cancer would also include MSI-H tumors.
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