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A pregnant affected person asks the nurse about the safe use of medications during the 0.33 trimester. alternative a. they may need to be given in better doses if they go through renal clearance.
Inside the zero.33 trimester, medications excreted with the aid of manner of the kidneys may also moreover be increased, because of the fact renal blood flow is doubled, the glomerular filtration fee is multiplied, and drug clearance is improved. Hepatic metabolism will increase, which means that capsules metabolized through the liver have to be elevated. All drugs can skip the placenta. Anatomic defects are more likely to occur within the embryonic length, that is in weeks 3 thru eight within the first trimester.
Hence, the answer is option A.
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a. They may need to be given in higher doses if they undergo renal clearance.
b. They require lower doses if they are metabolized by the liver.
c.They are less likely to cross the placenta and affect the fetus.
d. They are more likely to cause anatomical defects if they are teratogenic.
