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The uterine cycle's second phase, known as the proliferative phase, is when oestrogen stimulates the growth and proliferation of the uterine lining.
What are the steps in normal wound healing in the proliferative phase?
The uterine cycle's second phase, known as the proliferative phase, is when oestrogen stimulates the growth and proliferation of the uterine lining. The proliferative phase of the uterine cycle and the latter portion of the follicular phase coincide. The follicular or proliferative phase is the first stage of the menstrual cycle. Based on an average menstrual cycle length of 28 days, it happens from the first to the fourteenth day of the cycle.
Hemostasis, inflammation, proliferation, and remodeling are all components of the intricate biological process of wound healing. This process involves numerous cell types, including as neutrophils, macrophages, lymphocytes, keratinocytes, fibroblasts, and endothelial cells.
The proliferative phase of normal wound healing starts on the fourth day following damage and lasts for 2 to 4 weeks as the fibrin strands build a scaffold or framework and mitotic fibroblast cells move into the wound once the framework has been built. After that, collagen creates rigid scar tissue. Around the incision, capillaries create "buds" that develop into new blood vessels. As epithelial cells proliferate over the granulation tissue bed, these buds and a collagen deposit from the granulation tissue help the wound to close and fill.
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