In which cellular compartment do the three posttranscriptional modifications often seen in the maturation of mrna in eukaryotes occur?

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22-08-2022
Biology

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In which cellular compartment do the three posttranscriptional modifications often seen in the maturation of mrna in eukaryotes occur?

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Tutorconsortium356 Tutorconsortium356 · Answer 1 · 2022-08-27T20:47:07+02:00

In nucleus cellular compartment do the three posttranscriptional modifications often seen in the maturation of mrna in eukaryotes occur.

What is posttranscriptional modification?

The nucleus is where pre-mRNA is modified post-transcriptionally through processes including capping, splicing, and polyadenylation. The mature mRNA molecules must then be transported into the cytoplasm, where protein synthesis takes place, when these alterations are finished. Numerous nuclear proteins are attracted to the mRNA during the pre-mRNA processing stage in order to create RNA-protein complexes. Only a well processed mRNA will form an appropriate mRNA-protein complex, which is necessary to pass through the nuclear pore complexes. Therefore, a multi-subunit exosome complex that is specifically designed for RNA degradation will be used to degrade faulty mRNA and other byproduct RNA molecules, such as spliced-out introns. The human condition pontocerebellar hypoplasia type 1 has been related to mutations in EXOSC3, one of the exosome components.

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