The toxin of Vibrio cholerae causes the profuse diarrhea because it modifies a G protein involved in regulating salt and water secretion.
Cholera is an critical diarrheal disease which is caused by infection of the human intestine with vibrio cholerae bacteria. People get suffering when they swallow contaminated food or water with cholera bacteria.
Therefore, Vibrio cholerae infects the intestinal epithelial cells by releasing a cholera toxin called choleragen, and this Choleragen is a hexameric protein that consists of five binding B units and a single catalytic A unit, and this A unit binds onto the alpha G-protein in its GTP-phase and modifies G protein and cause diarrhea.
Learn more about vibrio cholerae here
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