In general, steroid and polypeptide hormones have one thing in common: they must circulate in the bloodstream.
The steroid hormones cortisol, 11-deoxycortisol, aldosterone, corticosterone, and 11-deoxycorticosterone are all primarily produced in the adrenal glands. The gonads and adrenal glands are the primary producers of the majority of other steroid hormones, including the estrogens.
Examples ; Glucocorticoids, mineralocorticoids, progestogens, estrogens, androgens
For a long time, polypeptide hormones (extracellular signals) have been acknowledged as crucial regulatory molecules in both animals and yeast. Polypeptides have been recognized as signals that control a wide range of physiological processes ever since insulin was discovered in 1922 (Banting and Best, 1922).
Examples: Pituitary hormones, antidiuretic hormone (vasopressin), and oxytocin are examples of peptide hormones that are polypeptide chains or proteins.
Steroid hormones quickly traverse plasma membranes and are lipid soluble. Hormones made of polypeptides and amino acids have longer half-lives in the circulation and so exert more signal amplification.
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