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The syndrome is used to describe an objectively identifiable aberration of the disease.

A disease is a detrimental deviation from the normal structural or functional state of an organism, generally associated with specific signs and symptoms, distinct from physical injury. A sick organism usually exhibits signs or symptoms indicative of its abnormal condition.

When ``illness'' was first used, it literally referred to ``lack of convenience or comfort,'' and today it is used to refer to illness and problems with bodily functions. Can be used to mean "offensive", but is usually hyphenated, as in "sickness". Infection. An infectious disease is a disease caused by the invasion of harmful substances (pathogens) into the body. The most common causes are viruses, bacteria, fungi, and parasites. The infection is usually passed from person to person through contaminated food, water, or insect bites.

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