The beta-ketoacyl synthase (KS), acetyl/malonyl transacylase (AT/MT), and other six catalytic activities are found in the FAS monomer, which is roughly 270 kDa in size.
The condensing enzymes that catalyze the reaction of acyl-coenzyme A (acyl-CoA) or acyl-acyl carrier protein (acyl-ACP) with malonyl-CoA, malonyl-ACP, or occasionally other substrates are known as ketoacyl synthases (KSs), more formally known as 3-oxoacyl synthases and also known as -ketoacyl synthases.
Between these active sites, the fatty acid chain is transported while being covalently bonded to the phosphopantetheine prosthetic group of an acyl carrier protein (ACP).
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