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5)in part b, the ph of the tris-glycine buffer used is 9.2 and the pi of normal human hemoglobin (hbahba) is 6.9. what is the net charge on normal human hemoglobin (hbahba), heterozygous (hbahbs) and sickle cell hemoglobin (hbshbs)? which electrode should each sample migrate toward during the electrophoretic separation? (2 points))

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Valine replaces glutamic acid in sickle cell anemia. The migration rate of HbSHBS relative to HbAHDA at pH 9.2 is shown in Part B along with its pi.

In sickle cell anemia, which amino acid replaces glutamic acid?

As a result, valine, a hydrophobic amino acid, is used instead of glutamic acid, a negatively charged sixth amino acid.

What happens when glutamic acid is used instead of valine?

Base substitution of glutamic acid to valine occurs at the appropriate place along the beta chain of the hemoglobin molecule in sickle cell anemia. This substitution occurs as a result of the single base change of the sixth codon of the beta globin gene from GAG to GUG.

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