Frameshift mutations are genetic alterations caused by deletions or insertions of DNA sequences that shift the way the sequence is read.
What are frameshift mutations?
- A frameshift mutation is a mutation that shifts the "reading frame" of a genetic message by adding or deleting nucleotides. An example is Tay-Sachs, a deadly disease that affects only Jewish babies and is most often fatal.
- An insertion or deletion of a number of base pairs that is not a multiple of 3 that disrupts the triplet reading frame of a DNA sequence is calledDNA Frameshift Mutation.
What is the effect of frameshift mutation?
Frameshift mutations are deletions or additions of 1, 2, or 4 nucleotides that alter the ribosomal reading frame and cause premature termination of translation at new nonsense or chain termination codons (TAA, TAG, and TGA).
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