Treatment with antiviral has no effect on the retrograde axonal transport of the infectious agent, while emetine blocks it regionally in axons.
It is generally agreed that retrograde neuronal transport is the only method of infectious agent (RABV) transmission. However, instances of RABV resulting in a high spread in periphery neurons, including DRG neurons, suggested a potential for bidirectional transport through an unidentified mechanism.
Rabies virus, Lagos bat, Mokola, Duvenhage, European bat virus 1 and also 2, as well as Australian bat virus are all species of the genus Lyssavirus.
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