Respuesta :
Yes, the genes are evolving under natural selection. R.A. Fisher hypothesized that the ubiquitous phenotypic alteration in PTC perception results from balanced natural selection in favor of heterozygotes.
What is Phenylthiocarbamide (PTC) perception?
Phenylthiocarbamide (PTC) taste is a typical trait that has been. Therefore, variation in PTC perception may represent variation in dietary preferences over the course of human history and may be associated with modern people' vulnerability to diseases. Because tasting other bitter compounds, many of which are poisonous, is correlated with the capacity to detect PTC, this feature has genetic, epidemiologic, and evolutionary significance associated with nutrition. We looked at patterns of DNA sequence variation in the recently discovered PTC gene, which contributes up to 85% of the trait's phenotypic variance, in order to test R. A. Fisher's well-known theory that natural selection has maintained variety in PTC perception. The entire code region was examined. In a sample of 330 chromosomes drawn from African (n=62), Asian (n=138), European (n=110), and North American (n=20) populations, we examined the entire coding region of PTC (1,002 bp) using new statistical tests for natural selection that take into account the potential confounding effects of human population growth. The "taster" and "nontaster" phenotypes were represented by two intermediate-frequency haplotypes, respectively. Similar haplotype frequencies were found in Africa, Asia, and Europe.
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