Sister chromatids separate in both stages, making meiosis II and mitosis most similar to one another. Sister chromatids split during meiosis II and mitosis.
As opposed to meiosis I, where the chiasma connecting two homologous chromosomes lines up on the metaphasal equator, meiosis II aligns the centromere between two sister chromatids on the equator.
DNA duplication occurs during both meiosis and mitosis in a cell. Each chromosome, or strand of DNA, is replicated and kept connected, creating two sister chromatids for each chromosome. Meiosis and mitosis both aim to divide the nucleus and its DNA content between two daughter cells.
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