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The answer to this question:
Insulin secreted by the pancreas, whereas glucagon secreted by the liver.

Insulin cause some cell take glucose, but glucagon cause THE LIVER to make glucose. Glucagon not works on all cell but insulin does. That mean insulin doesn't only work on muscle cells. 
Insulin secreted when the blood glucose level too high, but glucagon secreted when the blood glucose is too low.

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The main differences from the choices are:

> Insulin causes some cells to take up glucose, whereas glucagon cause some cells to secrete glucose.

>Insulin is secreted when the blood glucose level is low, whereas glucagon is secreted when the blood glucose level is high.

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