The enzyme affects the transition state by lowering it. It increases the rate of the reaction by lowering the activation energy of the reaction.
Enzymes are biocatalyst. They bind with the substrate and power the activation energy. It is the amount of energy that is required to start the reaction.
Enzymes affect the transition state, It stabilizes the structure of the transition state. It does not affect the Gibbs's free energy.
Thus, thus is affect the rate of reaction by increasing it. It lowers the activation energy and the transition state.
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