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Here are 4 explanations as to why men and women react differently to alcohol consumption: Capacity to dilute alcohol: While the concentration of water in the body of an average man is around 61 percent, a woman has a considerable less water content, that of 52 percent. As a result, a man”s body is naturally equipped to dilute alcohol more efficiently than a woman”s body – regardless of the weight factor.Capacity to metabolize alcohol: As mentioned earlier, women have lower concentrations of dehydrogenase – the enzyme that metabolizes alcohol before it passes into the bloodstream. So, a woman”s body processes alcohol comparatively slower than a man”s body would.Hormonal changes: Variations in the hormonal levels prior to menstruation can cause women to become intoxicated faster. This is especially evident during the days just before the commencement of the periods. Women who regularly take estrogen-added medications like birth control pills often experience extended effects of intoxication since the medication slows down the rate at which the body is able to eliminate the alcohol content.Body fat: The content of body fat is directly related to the rate of absorption and metabolizing of alcohol. Women have a higher concentration of body fat than men. Since fat does not absorb alcohol, the entire alcohol content remains in a highly concentrated form in the bloodstream. Consequently, women experience alcohol-induced intoxication faster than men.  Here is an article on how long does alcohol stay in your blood, you might find it helpful.